Design, Development and Evaluation of Pulsatile Drug Delivery System of Eprosartan Mesylate for Chronopharmacotheraphy

INTRODUCTION Pulsatile Drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. Pulsatile Drug Delivery systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, ABSTRACT The chronopharmacotherapy drug delivery system is widely used for treatment of diseases occurs due to circadian changes in the body. This system is aims to release drugs at a programmed pattern i.e.at appropriate time and/or at appropriate site of action. In this investigation, a novel oral pulsatile drug delivery system based on a core-in-cup dry coated tablet, where a core tablet surrounded on the bottom and circumference wall with inactive material. The system consists of three parts, a core tablet, containing the active ingredient, an impermeable outer shell and top cover layer of hydrophilic polymer. The core containing Eprosartan Mesylate as a bioactive compound was prepared by direct compression method and evaluated for thickness, hardness, weight variation and friability. The impermeable coating cup consisted of hydrophobic polymer of cellulose acetate propionate, and the top cover layer of hydrophilic swellable materials (Sodium Alginate, HPMC K4M, Sodium carboxy methylcellulose,) were used in different concentration. The tablets prepared were evaluated for Micromeritic properties, hardness, thickness, weight variation, friability, drug content uniformity and in-vitro drug release study. The drug-excipients study was carried out by using FT-IR. From the obtained results, it was found that the order of sustaining capacity of pulsatile device is, HPMC K4M > Sodium CMC > Sodium alginate.